PK/PD

Our services for in vivo assessment of PK/PD properties include but are not limited to:

• Standard formulation and specific formulation development
• Formulation screening
• Allometric dose prediction and PK optimization
• Single, multiple, and cassette dosing PK studies
• BBB penetration 
• Whole blood-to-plasma partitioning
• Stability in blood, plasma, gastric and intestinal fluids
• Mass balance and tissue distribution (traditional method and QWBA)
• Entero-hepatic recirculation (EHC)
• Renal and biliary excretion

Available species

MBeagle dog, Mini-pig and Cynomolgus monkey.

Administration routes

Oral (PO), intravenous (IV), intraarterial (IA), intramuscular (IM), intraperitoneal (IP), intratracheal (IT), subcutaneous (SC), transdermal (TD), intranasal (IN), IV infusion, SC infusion, rectal, and topical administration.

Surgical techniques

Bile-duct cannulation (BDC), jugular cannulation (JVC), portal vein cannulation (PVC), carotid artery cannulation (CAC), mesenteric lymph duct cannulation, bile-duct ligation, and castration.

Sample types

Whole blood, plasma, serum, bile, feces, urine, cerebrospinal fluid, bone marrow, lymph node, other fluids and tissues.

The features of our PK/PD services

• AAALAC-accredited animal facilities for a wide range of animal species
• State-of-the-art instruments
• Extensive experiences in PK model development with comprehensive in vivo techniques (surgical operation, animal care)
• Formulation support including formulation screening, development as well as formulation recommendation for various species and strains
• PK/PD data analysis, modeling, and simulation
• Regulatory documents support

PK/PD analysis is a key aspect of drug development. Understanding the bioavailability, exposure, half-life, clearance, and metabolism of a drug may determine the success or failure in the clinic. Creative Bioarray offers in vivo PK/PD services by utilizing our extensive expertise and models to support drug discovery and preclinical development for small molecules, peptides, nucleosides/nucleotides and biologics. All in-life work of PK/PD studies are carried out in AAALAC-approved animal facilities and follow IACUC-approved protocols. Whatever your needs, we work with you to identify the most appropriate models and to provide the customized study designs.